Guide of ZEBRA FISH

Zebra Fish - WARD\'S Natural Science
A Model Organism for Studying Vertebrate Life Cycle, Genetics, Embryology, and Development Zebra fish are an ideal organism to study vertebrate development in the classroom because they are easy to work with and are readily observable.
Some traits of zebra fish that make them perfect for classroom use include: • transparent embryos for easy observation • large eggs that are easier to observe than many invertebrates • embryos that develop faster than many other model vertebrates • mutant varieties that allow you perform genetic studies • controllable breeding cycles that can be worked into your class schedule • populations that are tolerant to a wide range of environmental factors for stress-free maintenance In addition, WARD’S zebra fish lab activities offer opportunities for study at all grade levels, provide long-term involvement for the entire class, and emphasize observation and critical thinking skills.
The zebra fish provided with all of WARD’S lab activities are raised in our own labs and are hand-selected, not collected from the wild, to ensure disease-free, genetically pure strains for genetics and other studies.


ZEBRA FISH

Gene-Altering Revolution Is About to Reach the Local Pet Store: Glow-in-the-Dark Fish - New York Times
In a development that is likely to inspire both fascination and alarm, a Texas company said yesterday that it would soon start selling a genetically engineered aquarium fish that glows in the dark.
The GloFish, as it is called, is a zebra fish containing a gene from a sea coral that makes the fish bright red under normal light and fluorescent under ultraviolet light.
Zebra fish, about an inch and a half long, are normally silver and black.
The company selling the fish, Yorktown Technologies, of Austin, calls the fish ''a miracle of science'' and said sales would begin Jan.
Making glow-in-the-dark fish extends the technology into the realm of human amusement, which might raise some eyebrows.
Some environmental groups, led by the Center for Food Safety in Washington, are trying to delay the sale of the fish for another reason, saying it should first be reviewed by federal regulators.
The groups say the fish might enter natural waterways if people dump out their aquariums and upset the natural balance in ecosystems.
He said that even if the GloFish was not dangerous, failure to regulate it would set a precedent allowing many other ornamental fish to enter the market unimpeded.

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info: ZEBRA FISH


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A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes -- Lyons et al. 99 (8): 5454 -- Proceedings of the National Academy of Sciences
Collins, National Institutes of Health, Bethesda, MD, and approved March 4, 2002 (received for review December 21, 2001) Vlad tepes ( vlt m651 ) is one of only five 'bloodless' zebrafish mutants isolated through large-scale chemical mutagenesis screening.
A BAC clone containing the zebrafish gata1 gene was able to rescue the bloodless phenotype in vlt m651 .
These results show that the vlt m651 mutation is a previously uncharacterized gata1 allele in the zebrafish.
The vlt m651 mutation sheds new light on Gata1 structure and function in vivo , demonstrates that Gata1 plays an essential role in zebrafish hematopoiesis with significant conservation of function between mammals and zebrafish, and offers a powerful tool for future studies of the hematopoietic pathway.
Boehm Conserved Functions of Ikaros in Vertebrate Lymphocyte Development: Genetic Evidence for Distinct Larval and Adult Phases of T Cell Development and Two Lineages of B Cells in Zebrafish J.
Watanabe Melk-Like Kinase Plays a Role in Hematopoiesis in the Zebra Fish Mol.

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Carl Zeiss MicroImaging GmbH: The Zebra Fish under the Microscope
As the zebra fish stays transparent throughout its development, it is an ideal model organism for the microscopical examination of vertebrate organ development.
Example 1: The zebra fish in cancer research In cancer research, the zebra fish is about to take the place of the mouse, which has been the established model organism so far.
This is because the developmental cycle of the mouse is longer, and the transparency of its ontogenetic stages lower, than that of the zebra fish.
Comparable hereditary eye defects can be found in zebra fish.
The development of the eye and the connections between the neurofibers in the eye are quite similar in humans and zebra fish.
The eyesight of zebra fish alevins is assessed by means of a special test.
The stereomicroscope allows the developing eyes of blind and sighted fish to be studied and compared with each other.
Strong impetus for zebra fish research The European Commission has granted €12m to promote studies of the zebra fish model.

ZEBRA FISH: